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What is sildenafil citrate? Sildenafil pills, sold under the brand name, Viagra, were initially developed for use as a medication for the treatment of hypertension (high blood pressure) and angina pectoris (chest pains as a result of a heart condition). This development was originally made by the pharmaceutical company, Pfizer, during which the clinical trials of the medicine indicated that the therapeutic may, in fact, be useful for inducing erections rather than its intended purposes.

Though it is not confirmed, these tablets are believed to be created by the researchers, Albert Wood and Peter Dunn, who saw the economic potential of these pills for the treatment impotence, through the biochemical effect brought out by its action. This therapeutic was patented in 1996 and approved for medical use by the Food and Drug Administration (FDA) two years later.

The clinical name of impotence is erectile dysfunction (ED), a term which was relatively new at that time but it did not take long for the medical condition to become widely known all around the world. Today you can find sildenafil for sale just about anywhere. In a study investigating the global prevalence of ED, the United States came up as the country with the highest rate of reported cases of impotence.

Moreover, it was estimated that at least 1 in ten men will experience ED at some point of their lives. Hence, the need of these tablets is expected to grow in the coming years as well. Generics of this medicine are available by the pharmaceutical companies, Teva and Pfizer. The cost effective sildenafil price is one of the many reasons why people find generic Viagra formulations more favorable than branded originals.

Read further to discover all there is to know, including answers to popular questions like; What is sildenafil citrate? How does sildenafil citrate work? And What are the sildenafil citrate side effects?

What is Sildenafil Citrate?

The common symptoms of erections problems include:

  • Reduced libido
  • Low self esteem
  • Inability to get an erection
  • Inability to keep an erection

Erectile dysfunction, according to Wisconsin Health (2019), affects approximately 10% of men per decade of their lives. This translates to 50% of men in their 50's, 60% of men in their 60's and so on. This erectile dysfunction medication is formulated with the active ingredient, sildenafil citrate. This active component of the tablets is responsible for the therapeutic action of increasing blood flow to the penis.

The active ingredient is the component of a medication which allows for the therapeutic effects to come to prominence. The formulation of medications is specifically designed to contain the correct amount of an active ingredient. Too much of the active ingredient can result in increased side effects, whilst too little of this component can render the medicament ineffective.

Different formulations of this ED medicine, such as the generic Viagra, all contain the same active ingredient, as required by the FDA. It is for this reason that the generic versions and the branded originals are similar in their therapeutic actions, side effects and risks as well. You can buy sildenafil online in both branded and generic form. Before you buy sildenafil, it is important to ensure that the medication is genuine in quality so that the tablets fulfill its intended purpose, as well as does not result in any or many adverse effects.

What is Sildenafil Used for?

The primary indication of this erectile dysfunction treatment is for management of erectile dysfunction symptoms. In other words, these tablets are used to attain or maintain an erection for sexual intercourse. This standard treatment can also be used by men who experience ED as a result of the condition, diabetes mellitus.

Research has also shown that these pills may be useful for the treatment of erectile dysfunction as a result of the use of anti-depressant medications. This condition is known as antidepressant-induced erectile dysfunction.

In addition to the treatment of impotence, other sildenafil uses include:

  • Pulmonary hypertension: the original intention of sildenafil citrate was for the treatment of high blood pressure. And even though these pills were reported as being more effective for inducing erections, they are still able to reduce the blood pressure levels in a patient as well. Sildenafil is used for the management of symptoms in those with pulmonary arterial hypertension.
  • Pulmonary edema: the Duke University School of Medicine, along with Dr. Richard Moon, has suggested the use of this ED medicine for the treatment of swimming-induced pulmonary edema. This is a health condition which is characterized by the build-up of water in the lungs that could ultimately lead to drowning.
  • Raynaud's phenomenon: this condition is characterized by the feelings of numbness and cold in certain areas of the body. This is due to the constriction of smaller arteries in response to cold and may limit blood supply to these areas. These ED pills can be used off-label to manage symptoms of this disease.
  • Sexual arousal in women: these tablets have been reported to be efficacious in increasing the sexual arousal of women. Though these improvements were observed in a small, selected group of female clinical trial patients, the use of sildenafil for women still remains unclear.

How Does Sildenafil Work?

Sildenafil works by increasing the flow of blood to the penis. This medication is classified as a phosphodiesterase type 5 (PDE5) inhibitor. PDE is an enzyme responsible for the breakdown of cAMP and cGMP. Both these substances are known for their role in the relaxation of smooth muscles. As a PDE5 inhibitor, the ED medication can prevent the breakdown of cAMP and cGMP, and hence lead to an accumulation of these substances to ultimately relax the smooth muscles.

The sildenafil mechanism of action acts to relax smooth muscles in the walls of blood vessels and thereby, stimulate the flow of blood to the penis. When this occurs, an erection is induced and allows the patient to effectively participate in sexual intercourse. These tablets do not function on their own. This means that sexual stimulation is a pre-requisite of sexual activity, in conjunction with the administration of these ED pills. Once sexual stimulation occurs, this medicine will assist in maintaining the erection.

Does sildenafil citrate work for any other condition? Yes, for pulmonary arterial hypertension, these pills function by relaxing the blood vessels in the chest. This, in turn, reduces the blood pressure of the patient.

How Long Does Sildenafil Last?

The duration of action of a medication is known as its 'half-life', and this is the time taken for half of the therapeutic to be removed from the body. The factors which affect how long erectile dysfunction pills can last depend upon:

  • The dosage administered: higher doses are an indication of greater amounts of a therapeutic in the body, and hence typically, a longer duration of action of the medicament. With that said, higher dosages do not necessarily mean there is a definitive extension of therapeutic action, as there can in some cases be no additional benefits with higher doses as compared to lower ones. Furthermore, higher dosages can also be related with an increased risk of side effects.
  • The genetic profiling of a patient: some people are able to breakdown medications in the body faster than others. This means that the duration of action of a therapeutic will not be the same for everyone.
  • Foods and drinks: some foods and drinks can interfere with the breakdown of a medicine and the subsequent absorption of the active ingredient into the bloodstream. Foods, such as high-fat meals, appear to delay therapeutic action by prolonging the breakdown of the medicament. This is because the fat-content in the meal delays gastric emptying, and hence the breakdown of the therapeutic.
  • Age: older individuals are believed to experience the therapeutic action of a medication with greater severity. This means that the duration of action of these tablets may be longer for seniors, as this age group may experience delayed elimination of the medicine as a result of their physiological conditions.

Sildenafil lasts for approximately four hours. Furthermore, it takes about an hour for the medication to reach peak concentrations in the blood.

Available Sildenafil Dosage

The available sildenafil citrate dosage amounts are as follows:

Sildenafil 100 mg tablet: this is the most popular sildenafil dosage and it is also the highest amount of the medicine which you can take over a 24 hour period. Sildenafil 100 mg should be taken at least 30 to 60 minutes prior to sexual intercourse and should also not be exceeded in the event that you do not see visible results. It is important to remember that sexual arousal is paramount for these tablets to be effective.

Sildenafil 50 mg tablet: a 50 mg sildenafil dosage is half of the dose most frequently used by men for the treatment of ED. Halving a dosage (using sildenafil 50 mg) is important for those who have impairments of the liver or kidneys, as these dysfunctions can interfere with the elimination of the medicament, and hence lead to an accumulation of the active ingredients in the body. This may result in heightened adverse effects.

Sildenafil 20 mg tablet: a 20 mg sildenafil tablet is the lowest dosage available and can be taken three times a day, at least four to six hours apart. A sildenafil 20 mg tablet can be used when initiating the treatment of impotence as the lower dosage formulation may be administered to analyze the effects of the therapeutic on the body.

The optimal sildenafil citrate dosage should always be decided by a medical professional.

Sildenafil Side Effects

Some of the sildenafil side effects include:

  • Facial flushing or hot flushes: these are described as feelings of warmth in the face and upper neck area. They can be in combination with reddening of the skin in the aforementioned areas as well. The 'flushing' of skin is as a result of the increased flow of blood, which is also the mechanism of action of ED pills.
  • Blurred vision: clinical trials have revealed that the use of high doses of these tablets can lead to visual impairments in otherwise healthy individuals. However, some sildenafil reviews have indicated this adverse event to be mild in severity as well as normally short-lived.
  • Headaches: these are pains occurring in the brain or head area of the body. Headaches are one of the most common side effects reported with any medication, and not solely related to ED tablets. Many men have reported that the headaches experienced as a side effect of this medication typically disappeared after a short while of using the tablets.

The above mentioned adverse events are not an exhaustive list and you can gain an insight to other additional side effects through online platforms, when you buy sildenafil from e-commerce pharmacies. Additional information pertaining to the use of this medicament advises against the use of sildenafil and alcohol in concordance, as doing so may lead to undesirable as well as life-threatening effects. Even when drinking alcohol in moderation, the interaction of these substances can lead to enhanced side effects of the medication.

Buy Sildenafil for Erectile Dysfunction

In a four year review by McCullough (2002), the effects of sildenafil citrate for the treatment of sexual dysfunction were evaluated. The key findings of this study indicated that:

  • These pills for the treatment of ED have revolutionized the medical and pharmaceutical world
  • The active ingredient of the medication continues to provide niches for the treatment of other diseases
  • These pills exemplify a near-perfect combination of the pharmaceutical industry with science and academic medicine
  • This therapeutic has improved the quality of life of millions of couples

The previously mentioned research study is an indication of the need for these ED tablets. Even though the prevalence of this sexual condition is higher among older men, more and more younger men (even in their 20's) have been reported to buy sildenafil online for the treatment of impotence. ED is thought to be the most commonly reported sexual dysfunction men reveal to their doctors. It affects as many as 30 million men, in fact, a 2019 review revealed the global prevalence of impotence to be between 3% and 76.5%.

With growing economic, environmental, financial and personal stresses, the prevalence of this sexual disorder is only thought to increase. This medication, and any Viagra alternative, is therefore imperative for the sexual health as well as the quality of life of millions of men. Buy sildenafil at Wizz Pharmacy and reap the benefits of this medication.

Dr Sophia Miller
Medically Review by:

Dr Sophia Miller

Dr Sophia Miller was born in New York City, USA. As a young woman, she was always interested in science, specifically; chemistry and she was determined to pursue a career in the field.

Checked: 15th March 2023
Review Due: March 2024


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