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How Does Flibanserin Work?

  • By: Dr Sophia Miller
  • Jun 25, 2021
How Does Flibanserin Work?

Flibanserin is a not a hormone as it does not contain estrogen or testosterone. Hormone pills are often used to replace the estrogen in the body after it is stopped being produced during menopause. This medication, on the other hand, does not contain hormones but works to influence the levels of certain hormones in the body. As you age, female sexual disorders become more prevalent and these can be relating to sexual arousal (low libido) as seen in women with female sexual interest arousal disorder (FSIAD). 

The condition is presented with a lack of interest in sexual activity and a lack of pleasure during sex, among other symptoms. Flibanserin is a medication, formulated by Sprout Pharmaceuticals, to improve low sex drive in pre-menopausal women with the previously mentioned female sexual arousal disorder. This therapeutic, when taken by mouth, is processed via the digestive system and released into the bloodstream where is involved in the production of dopamine and norepinephrine as well as the inhibition of serotonin. 

By affecting the activity of certain hormones in the body, normal sexual desire can be restored and by extension, the quality of life and sexual health in the patient may be improved. If you have been searching for information such as: 'How long flibanserin works', 'How flibanserin works' or 'How long until flibanserin works?', read ahead to find out all there is to know.

How Does Flibanserin Work to Treat FSIAD?

  • Flibanserin was originally designed as an anti-depressant medicine before it was repurposed for the treatment of low sex drive in females. This medication is classified as a multi-functional serotonin agonist/antagonist (MSAA). An agonist is a chemical that binds to a receptor and activates said receptor, and thus in the case of this medication, the active pharmaceutical ingredient (flibanserin) binds to the serotonin receptor and activates this component so as to decrease the activity of this hormone. The activity of serotonin is downregulated because this hormone is known to inhibit sexual desire.
  • As a multi-functional medication, this therapeutic also acts as an antagonist, which is a chemical that reduces or lowers a particular reaction. By lowering the levels of serotonin in the brain, the activity of this hormone can be further decreased so as to improve sexual desire.
  • Additionally, flibanserin pills function, in an indirect manner, to improve the symptoms of female sexual interest arousal disorder by increasing the amount of the dopamine and norepinephrine hormones in the brain as these chemical messengers take part in the sexual excitatory processes and are responsible for creating pleasure, as well as reducing stress.
  • The exact mechanism of action of this therapeutic is not well established but it is known that the above-mentioned influence on the production of certain neurotransmitters, or hormones, plays an important role in treating FSIAD.

How Long Until Flibanserin Works

When it comes to how quickly flibanserin works, it can take up to 4 weeks. This medication reaches steady-state concentrations after 3 days of administration. This means that the amount of medication in the body reaches a consistent level. The length of time that the medication takes to work can vary from person to person. Some people may see results within a few days, while others may need to take the medication for several weeks before they notice a difference.

There are a number of factors that can affect how fast flibanserin works, including:

  • The severity of the HSDD
  • Other medications that the person is taking
  • The persons age and overall health

Understanding how flibanserin works can help to use it effectively. The recommended dosage of this medication is 100 milligrams once daily, taken in the evening, before bedtime. People with conditions that affect blood pressure, such as high blood pressure or heart disease, should also talk to their doctor about how flibanserin works, to find out if it will be suitable. 

Additionally, women who are taking other medications that can lower blood pressure, such as antidepressants or blood pressure medications, should also talk to their doctor first. They will be able to confirm or deny the suitability of this medication.

How Long Will Flibanserin Work for?

When looking into how long flibanserin works, people will find that the duration of action of a flibanserin dosage is about 24 hours; this is the time it takes before the therapeutic benefits wear off. However, this duration is dependent on certain factors, such as age, metabolism and dosage, among others. In a study conducted by Goldfischer and researchers (2011), the continued efficacy of flibanserin was evaluated over a six month period in pre-menopausal women with the female sexual dysfunction

The findings of this study reported that the medication was superior to the placebo treatment in the following areas:

  • Overall sexual function
  • Sexual desire
  • Number of satisfying sexual events experienced over a specified period of time
  • Sexual distress

Furthermore, it was concluded at the end of the 24-week withdrawal phase of the clinical study that the patients using the medication for the treatment of FSIAD experienced no withdrawal symptoms at the end of the study and after a discontinuation of treatment. The overall use of this medicine was well-tolerated by the study population for six months but this therapeutic could probably be safely used for longer periods of time as well.

How Long Flibanserin Works for Depression

Aside from how fast flibanserin works, this medication has been shown to remain effective for up to 18 months after starting treatment. However, it is important to note that depression is an off-label use for this medication and it is not approved by the FDA for this. If you are considering taking this medication for depression, it is important to talk to a licensed physician beforehand.

As this medication affects the levels of serotonin and other neurotransmitters in the brain, it has been shown to reduce symptoms of anxiety and depression. In one study, women who were taking this medication reported a remission in their symptoms, meaning that they no longer met the criteria for depression. This is because it acts in a similar way to SSRI medications, which are mainly approved for this use.

When it comes to how long until flibanserin works when treating depression, improvements in mood can be felt in as little as a couple of days. However, how quickly flibanserin works for depression can also be dependent on how severe the symptoms are. The medication can help to improve symptoms but it is not guaranteed to work for everyone and is not a miracle cure. 

Will Flibanserin Work the Same for all Women?

  • There is no medication that can affect every single person in the exact same manner as all people are created differently and there are medical conditions and genetic profiling that are unique to patients. For example, those with a slower metabolism will process the medication at a reduced rate as compared to a patient with a fast metabolism and hence, the onset of action of a therapeutic can be delayed in these patients.
  • Unique body chemistry can also have an effect on other properties of flibanserin, such as the duration of action and the flibanserin side effects experienced by those using the medicine too.
  • Moreover, the effectiveness of this medicine is controversial, according to flibanserin reviews. This is because the medication is thought to only be efficacious in some women and not all who administer the tablets. There are some female patients that have not experienced any benefit when taking the pills as shown by the 50% of women who benefited from the medication in clinical trials. The general finding is that those with FSIAD should use flibanserin as the medication can be highly efficacious but if you do not notice any change in your sex drive after eight to twelve weeks of treatment, you should discontinue use.

Buy Flibanserin for FSIAD

Sexual health is the ability to experience pleasure and embrace the sexuality of your life. It is an important aspect that can have an effect on your mental, emotional and even physical well-being too. The consequences of a sexual dysfunction in women, such as FSIAD, can negatively affect the ability of a woman to engage in pleasurable sexual experiences. However, there is a solution to this problem that approximately 38% to 63% of women face (Jaafapour et. al., 2013).

You can buy flibanserin from a secure and reputable online pharmacy like ours for the effective treatment of low libido. When you search for this medication on our site, you can easily find details of this FSIAD treatment - such as the intended use, the advised dosages and more. Moreover, you can buy Addyi online in an approved generic formulation, simply known as flibanserin. 

This is the same as the branded version except at a far cheaper flibanserin price, since generic options are far more cost effective. Our online pharmacy ships using discreet packages and we accept Visa, MasterCard and Bitcoin. When payment is received we will invoice you and send you delivery information you can use to track delivery on the couriers webpage.

Contact us today to order safe and effective treatment, prescription free, for female sexual interest arousal disorder.

Dr Sophia Miller
Medically Review by:

Dr Sophia Miller

Dr Sophia Miller was born in New York City, USA. As a young woman, she was always interested in science, specifically; chemistry and she was determined to pursue a career in the field.

Checked: 15th March 2023
Review Due: March 2024

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